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| Untersuchte Arbeit: Seite: 22, Zeilen: 1-11 |
Quelle: Novosyadlyy 2004 Seite(n): 45-46, Zeilen: 45:26ff - 46:1-2 |
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| Periductal fibroblasts, which constitute a distinct subpopulation of mesenchymal cells in the portal tract, have been suggested to proliferate and transdifferentiate in response to bile duct ligation, causing periductal, periductular and periportal “biliary“ type of fibrosis. In schistosomiasis, vascular smooth muscle cells or vascular myofibroblasts situated in the wall of portal vein branches and portal arteries were thought to perpetuate to matrix-producing cells, thereby leading to periportal fibrosis as well. So called “second layer” cells are myofibroblasts located around the centrolobular vein. They were suggested to cause typical “alcoholic” type of pericentral fibrosis. Finally, capsular fibroblasts detected in Glisson’s capsule can also be a potential source of ECM in the liver (Cassiman et al., 2002; Knittel et al., 1999a; Ramadori and Saile, 2002).
Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T. 2002. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 36(2):200-209. Knittel T, Kobold D, Piscaglia F, Saile B, Neubauer K, Mehde M, Timpl R, Ramadori G. 1999a. Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol 112(5):387-401. Ramadori G, Saile B. 2002. Mesenchymal cells in the liver--one cell type or two? Liver 22(4):283-294. |
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Periductal fibroblasts, which constitute a distinct subpopulation of mesenchymal cells in the portal tract, have been suggested to proliferate and transdifferentiate in response to bile duct ligation, causing periductal, periductular and periportal „biliary“ type of fibrosis. In schistosomiasis, vascular smooth muscle cells or vascular myofibroblasts situated in the wall of portal vein branches and portal arteries were thought to perpetuate to matrix-producing cells, thereby leading to periportal fibrosis as well. So called „second layer“ cells are myofibroblasts located around the centrolobular vein. They were suggested to cause typical „alcoholic“ type of pericentral fibrosis. Finally, capsular fibroblasts [Page 46] detected in Glisson’s capsule can also be a potential source of ECM in the liver (Cassiman et al., 2002; Ramadori et al., 2002). 32. Cassiman D, Libbrecht L, Desmet V, Denef C and Roskams T (2002): Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 36: 200-9 120. Knittel T, Kobold D, Piscaglia F, Saile B, Neubauer K, Mehde M, Timpl R and Ramadori G (1999b): Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol 112: 387-401 190. Ramadori G and Saile B (2002): Mesenchymal cells in the liver – one cell type or two? Liver 22: 283-294 |
Identical up to the literary references. Not a hint of this text coming from somewhere else. |
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