von Ana Catarina Ribeiro Carrão
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| [1.] Arc/Fragment 020 03 - Diskussion Zuletzt bearbeitet: 2014-02-26 23:55:52 Hindemith | Arc, Fragment, Gesichtet, SMWFragment, Sampson et al 2007, Schutzlevel sysop, Verschleierung |
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| Untersuchte Arbeit: Seite: 20, Zeilen: 3-4 |
Quelle: Sampson et al 2007 Seite(n): 1 (online source), Zeilen: figures section |
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Fig. 3 – Diverse intracellular signalling pathways of the G-CSF Receptor. The cytoplasmic domain of the receptor contains Box 1 and Box 2 and Tyr704 in the proximal domain, necessary for mitogenesis. When phosphorylated, the four tyrosine residues serve as docking sites for SH2-containing proteins. Neither the structural basis of how cytosolic PTKs, such as Jak and Lyn, associate with the receptor, nor the specificity or redundancy of each tyrosine residue’s kinase are known28. 28. Basu S, Hodgson G, Zhang H-H, Katz M, Quilici C, Dunn AR. "Emergency" granulopoiesis in G-CSF-deficient mice in response to Candida albicans infection. Blood. 2000;95:3725-3733. |
Figure 1. Intracellular signaling pathways of the G-CSF Receptor. [...] The cytoplasmic domain of the receptor contains Box 1 and Box 2 and Tyr704 in the proximal domain, which is necessary for mitogenesis. [...] When phosphorylated, the four tyrosine residues serve as docking sites for SH2-containing proteins. [...] Neither the structural basis of how cytosolic PTKs, such as Jak and Lyn, associate with the receptor, nor the the specificity or redundancy of each tyrosine residue's kinase are known. |
The source is not mentioned here. Neither image nor caption can be found in Basu et al. (2000). |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Hindemith, Zeitstempel: 20140226235632