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Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes
Untersuchte Arbeit:
Seite: 15, Zeilen: 18-24
Quelle: James et al 2001
Seite(n): 267, Zeilen: left col 7-20
During eliciting of CSD the concentration of extracellular K+ rapidly rises (between 40-60mM), causing brief neuronal excitation then depolarization and a period of electrical silence during which DC potential at the brain surface falls. In tandem, [Na+]o and [Cl-]o levels decrease as these ions enter cells. Consequently, water enters cells, the extracellular compartment is reduced, and cells swell. Ca2+ ions also move inwards, but slightly later than the outward movement of K+, suggesting that Ca2+ movements follow K+ fluxes. Additional negative ion species move outwards to maintain electrical balance, the excitatory neurotransmitter glutamate probably [being the most important (Somjen et al., 2001).]

Somjen GG. Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev.; 2001;81:1065-96.

During CSD initiation the concentration of extracellular K+, [K+]o, rapidly rises, causing brief neuronal excitation then depolarization and a period of electrical silence during which the direct current (DC) potential at the brain surface falls. In tandem, [Na+]o and [Cl-]o levels decrease as these ions enter cells. Consequently, water enters cells, the extracellular space is reduced, and cells swellb. Ca2+ ions also move inwards, but slightly later than the outward movement of K+, suggesting that Ca2+ movements follow K+ fluxes. Additional negative ion species move outwards to maintain electrical balance, the excitatory neurotransmitter glutamate probably being the most importantc.

b Nicholson, C. and Kraig, R.P. (1981) The Application of Ion-Selective Microelectrodes (Zeuthen, T., ed.), pp. 217–238, Elsevier/North Holland Biomedical Press

c Szerb, J.C. (1991) Glutamate release and spreading depression in the fascia dentata in response to microdialysis with high K+: role of glia. Brain Res. 542, 259–265

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(Graf Isolan) Schumann
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