Reconsolidation: Behavioural and Electrophysiological Sequelae of Context and Stress in Human Episodic Memory
von Dr. Jennifer L. Moore
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| [1.] Jm/Fragment 004 05 - Diskussion Zuletzt bearbeitet: 2014-02-20 00:17:35 Schumann | Fragment, Gesichtet, Jm, SMWFragment, Schutzlevel sysop, Verschleierung, Wang et al 2008 |
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| Using drug cues as reinforcers, investigators reported that the β-adrenoreceptor antagonist propranolol, administered after reactivation of cocaine or morphine conditioned place preference (CPP), impairs drug seeking via disruption of reconsolidation (Bernardi et al., 2006; Robinson & Franklin, 2007). | Using drugs as reinforcers, investigators reported that the β-adrenoreceptor antagonist propranolol, administered after reactivation of cocaine or morphine conditioned place preference (CPP), impairs drug seeking via disruption of reconsolidation (Bernardi et al., 2006; Robinson and Franklin, 2007). |
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| [2.] Jm/Fragment 004 10 - Diskussion Zuletzt bearbeitet: 2014-01-13 07:45:34 Graf Isolan | BauernOpfer, Fragment, Gesichtet, Jm, Lee et al 2005, SMWFragment, Schutzlevel sysop |
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| Lee and colleagues (2005) found that infusions of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala of rats, prior to the reactivation of a well-learned memory for a conditioned stimulus (CS)-cocaine association, abolished the acquired conditioned reinforcing properties of the drug-associated stimulus and thus its impact on the learning of a new cocaine-seeking response. Furthermore, it was shown that reconsolidation of CS-fear memories also requires Zif268 in the amygdala. These results demonstrate that appetitive CS-drug memories undergo reconsolidation in a manner similar to aversive memories and that this amygdala-dependent reconsolidation can be disrupted to reduce the impact of drug cues on drug seeking.
Lee, J.L., Di Ciano, P., Thomas, K.L., & Everitt, B.J. (2005). Disrupting reconsolidation of drug memories reduces cocaine-seeking behaviour. Neuron, 47, 795-801. |
Here, we show that infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala, prior to the reactivation of a well-learned memory for a conditioned stimulus (CS)-cocaine association, abolishes the acquired conditioned reinforcing properties of the drug-associated stimulus and thus its impact on the learning of a new cocaine-seeking response. Furthermore, we show that reconsolidation of CS-fear memories also requires Zif268 in the amygdala. These results demonstrate that appetitive CS-drug memories undergo reconsolidation in a manner similar to aversive memories and that this amygdala-dependent reconsolidation can be disrupted to reduce the impact of drug cues on drug seeking. |
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| [3.] Jm/Fragment 004 19 - Diskussion Zuletzt bearbeitet: 2014-01-12 21:48:59 Graf Isolan | Fragment, Gesichtet, Jm, KomplettPlagiat, SMWFragment, Schutzlevel sysop, Wang et al 2008 |
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| Untersuchte Arbeit: Seite: 4, Zeilen: 19-25 |
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| Morphine CPP is persistently disrupted when anisomycin, a protein synthesis inhibitor, is administered after a conditioning session (Milekic et al., 2006). When mice previously conditioned for cocaine place preference are re-exposed to cocaine in the drug-paired compartment after systemic administration of SL327, an inhibitor of ERK (extracellular signal-regulated protein kinase) activation, CPP response is abolished (Valjent et al., 2006). Together, drug-related memory can be inhibited or erased by interrupting its reconsolidation process. | Morphine CPP is persistently disrupted when anisomycin, a protein synthesis inhibitor, is administered after a conditioning session (Milekic et al., 2006). When mice previously conditioned for cocaine place preference are re-exposed to cocaine in the drug-paired compartment after systemic administration of SL327 [α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl) benzeneacetonitrile], an inhibitor of ERK (extracellular signal-regulated protein kinase) activation, CPP response is abolished (Valjent et al., 2006a). Together, drug-related memory can be inhibited or erased by interrupting its reconsolidation process. |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Graf Isolan, Zeitstempel: 20140113074753
Letzte Bearbeitung dieser Seite: durch Benutzer:Graf Isolan, Zeitstempel: 20140113074753