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| Human haematopoietic stem cells (hHSCs) are rare small mononuclear cells
that tend to be noncycling or to have long cell cycles. They divide to form more hHSCs (self-generation or symmetric division) [...] These immature progenitors are committing to lymphocyte progenitor formation (common lymphoid progenitors, CLPs) or to the formation of myeloid progenitors (common myeloid progenitors, CMPs). CMPs are large blast cells that can then form megakaryocyteerythroid progenitors (MEPs) committed to the formation of erythroid and megakaryocytic cell lineages. CMPs can also form more restricted granulocyte-macrophage progenitors (GMPs) that are able to generate granulocytic, macrophage, and eosinophil progenitors. These lineage-restricted cells can generate respective mature lineage populations. 17-20 17.Kondo M, Scherer DC, Miyamoto T, et al. Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Nature. 2000;407:383-386. 18.Kondo M, Wagers AJ, Manz MG, et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol. 2003;21:759-806. 19.K A. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. . Bllod. 2003;101:383-389. 20.Shizuru JA, Negrin RS, Weissman IL. Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med. 2005;56:509-538. |
Hematopoietic stem cells (HSCs) are rare (1 per 105 bone-marrow cells), small mononuclear cells that tend to be noncycling or to have long cell cycles. HSCs divide to form more HSC (self-generation) or to form cells committed either to lymphocyte formation (common lymphoid progenitors, CLPs) or to the formation of myeloid cells (common myeloid progenitors, CMPs) (Figure 1). CMPs are large blast cells that can then form megakaryocyteerythroid progenitors (MEPs) committed to the formation of erythroid and megakaryocytic progeny. CMPs can also form more restricted granulocyte-macrophage progenitors (GMPs) able to generate granulocytic, macrophage, and eosinophil progenitors and, through these lineage-restricted cells, generate respective mature populations (Kondo et al., 1997; Akashi et al., 2000).
Akashi, K., Traver, D., Miyamoto, T., and Weissman, I.L. (2000). A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193–197. Kondo, M., Weissman, I.L., and Akashi, K. (1997). Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661–672. |
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