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| Untersuchte Arbeit: Seite: 16, Zeilen: 6-18 |
Quelle: Wikipedia hematopoietic stem cell 2008 Seite(n): 1 (online source), Zeilen: - |
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| Using limiting dilution strategies combined with other streamlined experimental and statistical methods for examining HSCs at the clonal level, HSCs fall into three distinct lineage-biased clusters.56-58 These are quantitatively defined by the ratio “ρ” of lymphoid to myeloid cells that the HSC generates upon differentiation (which makes ñ [sic] a peripheral predictor for the clonal association of a reconstituted haematopoietic system). Balanced HSCs repopulate peripheral white blood cells in the same ratio of myeloid to lymphoid cells as seen in unmanipulated mice (on average about 15% myeloid and 85% lymphoid cells, or 3≤ñ≤10 [sic]), in the NOD/SCID mice. Myeloid-biased (My-bi) HSC give rise to too few lymphocytes resulting in ratios 0<ρ<3, whereas lymphoid-biased (Ly-bi) HSC generate too few myeloid cells, which results in lymphoid-to-myeloid ratios of 10<ρ<00 [sic]. All three types are normal HSCs in the sense that they have self-renewal capacity and can regenerate all haematopoietic lineages (pluripotency).
56. Muller-Sieburg [sic] CE, Cho RH, Thoman M, Adkins B, Sieburg HB. Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. Blood. 2002;100:1302-1309. 57. Muller-Sieburg [sic] CE, Cho RH, Karlsson L, Huang JF, Sieburg HB. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood. 2004;103:4111-4118. 58. Sieburg HB, Cho RH, Dykstra B, Uchida N, Eaves CJ, Muller-Sieburg [sic] CE. The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood. 2006;107:2311-2316. |
Using limiting dilution strategies combined with other streamlined experimental and statistical methods for examining HSCs at the clonal level, it was shown that HSCs fall into three distinct lineage-bias[1] [2] [3] clusters. These are quantitatively defined by the ratio ρ of lymphoid to myeloid cells that HSC generate upon differentiation (which makes ρ a peripheral predictor for the clonal association of a reconstituted hematopoietic system). Balanced HSCs repopulate peripheral white blood cells in the same ratio of myeloid to lymphoid cells as seen in unmanipulated mice (on average about 15% myeloid and 85% lymphoid cells, or 3≤ρ≤10). Myeloid-biased (My-bi) HSC give rise to too few lymphocytes resulting in ratios 0<ρ<3, whereas lymphoid-biased (Ly-bi) HSC generate too few myeloid cells, which results in lymphoid-to-myeloid ratios of 10 < ρ < oo. All three types are normal HSC in that they have self-renewal capacity and can regenerate all hematopietic [sic] lineages (pluripotency).
1. Muller-Sieburg [sic] CE, Cho RH, Thoman M, Adkins B, Sieburg HB, Deterministc [sic] regulation of hematopoietic stem cell self-renewal and differentiation. Blood. 2002; 100; 1302-9 2. Muller-Sieburg [sic] CE, Cho RH, Karlson [sic] L, Huang JF, Sieburg HB. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished progeny with impaired IL-7 responsiveness. Blood. 2004; 103:4111-8. 3. Sieburg HB, Cho RH, Dykstra B, [sic] Eaves, CJ, Muller-Sieburg [sic], CE. The hematopoietic stem cell [sic] compartment consists of a limited number of discrete stem cell subsets. Blood. 2006; 107:2311-6. Epub 2005 Nov 15. |
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