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| Untersuchte Arbeit: Seite: 44, Zeilen: 1-6 |
Quelle: Gordon et al 2010 Seite(n): 2267, Zeilen: 26-31 |
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| [Additionally, treatment of LNCaP cells with the CDK9 inhibitors, 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and Flavopiridol, reduced] Ser81 phosphorylation further, suggesting that CDK9 regulates Ser81 phosphorylation. Pharmacological inhibition of CDK9 also resulted in decreased AR transcription in LNCaP cells. Collectively these results suggest that CDK9 phosphorylation of AR Ser81 is an important step in regulating AR transcriptional activity and prostate cancer cell growth. | Additionally, treatment of LNCaP cells with the CDK9 inhibitors, 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and Flavopiridol, reduced S81 phosphorylation further, suggesting that CDK9 regulates S81 phosphorylation. Pharmacological inhibition of CDK9 also resulted in decreased AR transcription in LNCaP cells. Collectively these results suggest that CDK9 phosphorylation of AR S81 is an important step in regulating AR transcriptional activity and prostate cancer cell growth. |
Continues from the previous page. Although nearly identical, nothing has been marked as a citation. Gioeli is one of the co-authors of Gordon et al 2010. |
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