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| Untersuchte Arbeit: Seite: 77, Zeilen: 1-5 |
Quelle: Gu et al 2009 Seite(n): 0, Zeilen: 0 |
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| [Since p53 is a frequently inactivated gene in tumors, it is interesting to hypothesize that mAR activation] may result in eradication of p53 tumors in vivo. Notwithstanding the above, and despite the fact that additional experiments are required for the detailed evaluation of mAR-dependent biological effects in colon cancer, our data support the recently postulated notion [Papadopoulou N, et al. 2009] that mAR may represent a novel specific tumor target.
Papadopoulou N, Papakonstanti EA, Kallergi G, Alevizopoulos K, Stournaras C. (2009). Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact. IUBMB Life, 61(1): 56-61. |
Since p53 is a frequently inactivated gene in tumors, it is interesting to hypothesize that mAR activation may result in eradication of p53 tumors in vivo. [...]
Despite the fact that additional experiments are required for the detailed evaluation of mARdependent biological effects in colon cancer, our findings fully enforce the potential significance of the recently postulated notion [17] that mAR may represent a novel and specific tumor target. 17. Papadopoulou N, Papakonstanti EA, Kallergi G, Alevizopoulos K, Stournaras C: Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact. IUBMB Life 2009, 61(1):56-61 |
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