FANDOM


Role of Serum and Glucocoritcoid [sic] inducible Kinase SGK1 in the regulation of glucose transport

von Dr. Sankarganesh Jeyaraj

vorherige Seite | zur Übersichtsseite | folgende Seite
Statistik und Sichtungsnachweis dieser Seite findet sich am Artikelende
[1.] Sj/Fragment 003 01 - Diskussion
Zuletzt bearbeitet: 2016-11-24 19:41:32 Schumann
Fragment, Gesichtet, Li 2004, SMWFragment, Schutzlevel sysop, Sj, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes
Untersuchte Arbeit:
Seite: 3, Zeilen: 1-10
Quelle: Li 2004
Seite(n): 11, Zeilen: 5 ff.
In the triggering pathway, the facilitative glucose transporter GLUT2 transports the glucose into the β cell. It causes the rise in the ratio of ATP/ADP which leads ATP-sensitive K+ channels (KATP channels) in the plasma membrane to close. The decreased K+ permeability leads to membrane depolarization, opening of voltage-dependent Ca2+ channels, Ca2+ influx, and the eventual rise of the cytosolic Ca2+ concentration ([Ca2+]c) that triggers exocytosis of insulin containing vesicles. This pathway is also called KATP channel-dependent pathway. Please see Figure 1 for an illustration. The amplifying pathway which is a KATP channel-independent pathway, simply increases the efficiency of the Ca2+ on exocytosis when the concentration of Ca2+ has been elevated. Triggering Pathway The GLUT2 transports the glucose into the β cell. It causes the rise in the ratio of ATP/ADP which causes ATP-sensitive K+ channels (KATP channels) in the plasma membrane to close. The decreased K+ permeability leads to membrane depolarization, opening of voltage-dependent Ca2+ channels, Ca2+ influx, and the eventual rise of the cytosolic Ca2+ concentration ([Ca2+]c) that triggers exocytosis. This pathway is also called KATP channel-dependent pathway. See Figure 1.3.2 for an illustration.

Amplifying Pathway The KATP channel-independent pathway simply increases the efficiency of the Ca2+ on exocytosis when the concentration of Ca2+ has been elevated.

Anmerkungen

The two described figures are not identical.

The source is not mentioned.

Sichter
(Hindemith) LieschenMueller

[2.] Sj/Fragment 003 12 - Diskussion
Zuletzt bearbeitet: 2016-11-25 19:31:57 WiseWoman
Fragment, Gesichtet, Li 2004, SMWFragment, Schutzlevel sysop, Sj, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes
Untersuchte Arbeit:
Seite: 3, Zeilen: 12-14
Quelle: Li 2004
Seite(n): 12, 13, Zeilen: 12: 4ff; 13: 17ff
Figure 1. Pancreatic beta cells secrete insulin when glucose concentration levels are elevated.

The facilitated glucose transporter GLUT2 transports the glucose into the cell where it is phosphorylated by glucokinase. The glucose metabolism causes ATP-sensitive K+ channels to close, the membrane to depolarize and the Ca2+ channels to open. This triggers a cascade of protein phosphorylations leading to insulin exocytosis.

The insulin receptor is a transmembrane glycoprotein that belongs to the large class of tyrosine kinase receptors. Two α subunits and two β subunits make up the insulin receptor. The β subunits pass through the cellular membrane and are linked by disulfide bonds (10) .


10. Ackermann,AM, Gannon,M: Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J.Mol.Endocrinol. 38:193-206, 2007

Figure 1.3.2. The β cells secrete insulin when glucose concentration level elevated

The facilitated GLUT2 transport the glucose into the β cell and the glucose is phosphorylated by glucokinase. The ratio of ATP:ADP is elevated. The glucose metabolism causes ATP-sensitive K+ channels to close, the membrane to depolarize and the Ca2+ channels to open. This triggers a cascade of protein phosphorylations and leads to insulin exocytosis [68]. (The figure is partially adapted from [68].)

[page 13]

3.4. Insulin Receptors. In molecular biology, the insulin receptor is a transmembrane glycoprotein that is activated by insulin. It belongs to the large class of tyrosine kinase receptors. Two α subunits and two β subunits make up the insulin receptor. The β subunits pass through the cellular membrane and are linked by disulfide bonds ([90]).


[68] V. Poitout, An integrated view of β-cell dysfunction in type-II diabetes, Annu. Rev. Med. 1996. 47:6983.

[89] http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/pancreas/index.html

Anmerkungen

The source is not given.

The two figures with nearly identical captions are in fact quite different.

Sichter
(Hindemith), PlagProf:-)


vorherige Seite | zur Übersichtsseite | folgende Seite
Letzte Bearbeitung dieser Seite: durch Benutzer:WiseWoman, Zeitstempel: 20161125193926
Nutzung von Community-Inhalten gemäß CC-BY-SA , sofern nicht anders angegeben.