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| Untersuchte Arbeit: Seite: 26, Zeilen: 15-29 |
Quelle: Pervaiz and Clement 2007 Seite(n): 1297, 1298, Zeilen: 1297: l. Spalte: 4ff; 1298: r. Spalte: 13ff |
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| The major reactive oxygen species (ROS) include oxygen radicals such as superoxide (O2−) and hydroxyl (OH), as well as non-radical derivatives of molecular oxygen (O2), such as hydrogen peroxide (H2O2). Whereas O2− and H2O2 do not exhibit strong reactivity with other bio-molecules, their reaction generates the highly reactive OH radical, which probably accounts for most of the oxidative damage attributed to ROS (Halliwell & Gutteridge, 1999).
In healthy living cells, one or more of redox regulatory mechanisms are activated in response to a transient increase in intracellular ROS to prevent oxidative stress. A disturbance in the tight balance between ROS production and elimination, either via augmentation of ROS generation or defective/deficient anti-oxidant defenses for their elimination, results in a build up of intracellular ROS and may lead to persistent changes in signal transduction and gene expression (Sauer et al., 2001), thereby giving rise to oxidative stress-related pathological states (Burdon, 1995 and Burdon, 1996). |
Leaving aside the reactive nitrogen species, the major reactive oxygen species (ROS) include oxygen radicals such as superoxide (O2 −) and hydroxyl (•OH), as well as non-radical derivatives of molecular oxygen (O2), such as hydrogen peroxide (H2O2) (Fridovich, 1978). Whereas O2 − and H2O2 do not exhibit strong reactivity with other bio-molecules, their reaction generates the highly reactive •OH radical, which probably accounts for most of the oxidative damage attributed to ROS (Halliwell & Gutteridge, 1999).
[Seite 1298] In healthy living cells, one or more of these redox regulatory mechanisms are activated in response to a transient increase in intracellular ROS to prevent oxidative stress. A disturbance in the tight balance between ROS production and elimination, either via augmentation of ROS generation or defective/deficient anti-oxidant defenses for their elimination, results in a build up of intracellular ROS and may lead to persistent changes in signal transduction and gene expression, thereby giving rise to oxidative stress-related pathological states. |
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