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Untersuchte Arbeit:
Seite: 45, Zeilen: 24-30
Quelle: Müller 2002
Seite(n): 12, Zeilen: 25ff
Wie kein anderes Enzym reagiert die HO-1 extrem empfindlich auf verschiedene Stresssoren, insbesondere auf Stimuli, die oxidativen Stress verstärken. Dazu gehören H2O2, Lipopolysacharide, NO, Ischämie, Heat Shock Proteine, Hypoxie und Hyperoxie (Wagener FA et al., 2003), I/R, (Takahashi S et al., 1999), inflammatorische Zytokine (Amersi F et al., 1999; Kudo S et al., 1999; Rizzardini M et al., 1993; Terry CM et al., 1998), Endotoxine (Amersi F et al., 1999; Camhi SL et al., 1995; Pellacani A et al., 1998), Häm (Taylor JL et al., 1998; Vesely MJ et al., 1998), Metalle (Immenschuh S et al., 1995), Hypothermie, [Hyperthermie (Shibahara S et al., 1987) sowie die portale Hypertension (Fernandez M et al., 1999).] Wie kein anderes Enzym, reagiert die HO-1 extrem empfindlich auf verschiedene Stresssoren, w.z.B. I/R, Hypoxie, Hyperoxie [110], inflammatorische Zytokine [5, 59, 96, 112], Endotoxin [5, 16, 92], Häm [111, 116], Metalle [43], Hypothermie, Hyperthermie [102] sowie die portale Hypertension [33] [Abb. 1].

5 Amersi F, Buelow R, Kato H, Ke B, Coito AJ, Shen XY, Zhao D, Zaky J, Melinek J, Lassman CR, Kolls JK, Alam J, Ritter T,Volk HD, Farmer DG, Ghobrial RF, Busuttil RW, Kupiec-Weglinski JW. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J Clin Invest 1999;104(11):1631-9.

16 Camhi SL, Alam J, Otterbein L, Sylvester SL, Choi A. Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol 1995; 13:387-98.

33 Fernandez M, Bonkovsky HL. Increased heme oxygenase-1 gene expression in liver cells and splanchnic organs from portal hypertensive rats. Hepatology 1999;29(6):1672-9.

43 Immenschuh S, Iwahara S, Satoh H, Nell C, Katz N, Muller-Eberhard U. Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells. Biochemistry 1995;34(41):13407-11.

59 Kudo S, Kawano K. Role of interleukin-1 beta in the modulations of cytochrome P450 and heme metabolism in rat liver. J Interferon Cytokine Res 1999;19(6):601-7.

92 Pellacani A, Wiesel P, Sharma A, Foster LC, Huggins GS, Yet SF, Perrella MA. Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1. Circ Res 1998;83(4):396-403.

96 Rizzardini M, Terao M, Falciani F, Cantoni L. Cytokine induction of haem oxygenase mRNA in mouse liver: Interleukin 1 transcriptionally activates the haem oxygenase gene. Biochem J 1993;290:343-347.

102 Shibahara S, Muller RM, Taguchi H. Transcriptional control of rat heme oxygenase by heat shock. J Biol Chem 1987;262(27):12889-92.

110 Takahashi S, Takahashi Y, Ito K, Nagano T, Shibahara S, Miura T. Positive and negative regulation of the human heme oxygenase-1 gene expression in cultured cells. Biochim Biophys Acta 1999;1447(2-3):231-5.

111 Taylor JL, Carraway MS, Piantadosi CA. Lung-specific induction of heme oxygenase-1 and hyperoxic lung injury. Am J Physiol 1998;274(4 Pt 1):L582- 90.

112 Terry CM, Clikeman JA, Hoidal JR, Callahan KS. Effect of tumor necrosis factor-α and interleukin-1α on heme oxygenase-1 expression in human endothelial cells. Am J Physiol 1998;274(heart circ physiol 43): H883-91.

116 Vesely MJ, Exon DJ, Clark JE, Foresti R, Green CJ, Motterlini R. Heme oxygenase-1 induction in skeletal muscle cells: hemin and sodium nitroprusside are regulators in vitro. Am J Physiol 1998;275(4Pt1):C1087-94.

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