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Quelle: Owens and Hawley 2002 Seite(n): 365, 371, Zeilen: 365, right col., 16-22, 41-44; 371, left col., 11-16 |
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| 1.3.2 Non-clustered homeobox genes in leukemogenesis
Several non-clustered HD proteins have been shown to function as cofactors for HOX proteins, interacting with HOX genes by a conserved sequence YPWMK and are co-expressed during embryonic development. These include the three-amino-acid-loop-extension (TALE) proteins, PBX, MEIS, and PREP1/KNOX1. PBX genes are widely expressed in fetal and adult tissues, although PBX1 transcripts are notably absent from lymphocytes (Monica et. al., 1991). The hematopoietically expressed (HEX) gene as another example of a non-clustered homeobox gene was initially identified in human hematopoietic cells, where it is expressed in multipotential progenitors, myeloid cells, and B cells, but not T or erythroid cells (Bedford et. al., 1993). HEX expression has also been detected in peripheral blood leukocytes from leukemia patients (Manfioletti et. al., 1995). Other non-HOX HB genes like HOX11, and members of the CDX, HLX, and PMX1 families are more restricted in their patterns of expression, and are involved in organogenesis or differentiation of specific cell types. |
[page 365]
Several non-HOX HD proteins have been shown to function as cofactors for HOX proteins and are cosynthesized during embryonic development. These include the three-amino-acid-loop-extension (TALE) proteins, PBX, MEIS, and PREP1/KNOX1. PBX genes are widely expressed in fetal and adult tissues, although PBX1 transcripts are notably absent from lymphocytes [28]. [...] Other non-HOX HB genes are more restricted in their patterns of expression, and their encoded HD proteins are involved in organogenesis or differentiation of specific cell types. [page 371] HEX (hematopoietically expressed HB; Hhex/Prh) was initially identified in human hematopoietic cells, where it is expressed in multipotential progenitors, myeloid cells, and B cells, but not T or erythroid cells [127]. HEX expression has also been detected in peripheral blood leukocytes from leukemia patients [127, 128] 28 Monica K, Galili N, Nourse J et al. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol 1991;11:6149-6157. 127 Bedford FK, Ashworth A, Enver T et al. HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res 1993;21:1245-1249. 128 Manfioletti G, Gattei V, Buratti E et al. Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells. Blood 1995;85:1237-1245. |
The only reference to the source is made on p.6. |
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